Efficacy and CRS profiling of bispecific T-cell engagers
Are you developing multispecifics? This case study walks through how we profile a bispecific T-cell engager end to end — efficacy, mechanism, and cytokine-release liability — using tarlatamab, a CD3×DLL3 engager for small-cell lung cancer, as the worked example. We start on DLL3-positive small-cell lung cancer cells (SHP77) against a DLL3-negative NSCLC control (A549), confirm […]
STAMP- Xenium for cytokine release syndrome analysis in PBMCs
Presented at the 10x Genomics x Novartis Single-Cell & Spatial Day on June 18th 2026, this cytokine release syndrome study in human PBMCs combines Cytometric Bead Array (CBA)-based cytokine profiling and Xenium analysis with the IO panel. The take-home message: CBA + Xenium STAMP lets you know what is secreted, by which cells, and through […]
Sample multiplexing for Xenium – Bioptimus x Explicyte Case Study
This study in partnership with AI company Bioptimus addresses cost and throughput. We doubled the number of FFPE samples per Xenium slide and ran a rigorous head-to-head against the “standard” format. Across QC metrics, cell-type proportions, and gene expression profiles, the data held up — with sample-to-sample correlations between formats reaching near-perfect agreement. This sample […]
Xenium beyond 5k
On a cohort of FFPE PDAC samples, we tested whether matched scRNAseq data could unlock biology hidden from the Xenium 5K panel. By integrating scRNA-seq data with Xenium, we substantially improved cluster annotation and resolved cell populations that were partially merged in the standard Xenium analysis — including B-cell populations, for example. The rationale is straightforward: […]
Smarter Xenium: More Biology per Slide, More Value per Sample
At the 10x Genomics Atera World Tour 2026 in Paris, Explicyte presented two case studies tackling the question every spatial biology team faces: how do we extract more biological value from FFPE tumor samples, while keeping turnaround time and cost under control? The challenge: spatial transcriptomics at scale Single-cell spatial transcriptomics is now a production […]
Cure51 – A unique Xenium dataset of cancer outliers
