Publications

Peer-reviewed work from our oncology programs — spatial omics, multiplex protein, and bulk transcriptomics across the drug-development pipeline.

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44 publications

Jul 2026 · Cell Reports

Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a membrane-bound TGF-β1-dependent mechanism

BreastDiscoveryTarget discoveryTarget validationFFPE tissueImmune/tumor cell co-culturePBMCscRNAseq

Jul 2026 · Cancer Cell

GABA promotes resistance to immunotherapy in patients with TLS-positive tumors

Bone and soft tissueGenitourinaryBiomarker analysisBiomarker discoveryDiscoveryTarget discoveryTLS scoringTrialsFFPE tissueFresh-frozen tissueMousePBMCMetabolomicsMultiplex IF/IHCRNAseqVisium HD

Feb 2026 · Clinical Cancer Research

Adenosine A2B Receptor Promotes Tumor Progression and Metastases in Undifferentiated Pleomorphic Sarcoma

Bone and soft tissueBiomarker discoveryTarget discoveryFFPE tissueBioinformaticsGeoMx DSPMultiplex IF/IHC

Dec 2025 · Science Advances

Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin

SkinBiomarker analysisDiscoveryTrialsFFPE tissueFresh-frozen tissueFlow cytometryMultiplex IF/IHCscRNAseq

Oct 2025 · Cancer Cell

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

BreastGenitourinarySkinBiomarker analysispre/post studyTLS scoringTrialsFFPE tissueMultiplex IF/IHC

Jun 2025 · Signal Transduction and Targeted Therapy

Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumab

Bone and soft tissueBiomarker analysispre/post studyTLS scoringTrialsFFPE tissueBioinformaticsMultiplex IF/IHCProteomics

Apr 2025 · Nature Cancer

Regorafenib plus avelumab in advanced gastroenteropancreatic neuroendocrine neoplasms: a phase 2 trial and correlative analysis

EndocrineGastrointestinalBiomarker analysisBiomarker discoveryDiscoveryTrialsFFPE tissuePlasmaBioinformaticsMetabolomicsMultiplex IF/IHCProteomics

Feb 2025 · Cell Reports Medicine

Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structures

ThoracicBiomarker analysisBiomarker discoveryDiscoveryTarget discoveryTLS scoringTrialsFFPE tissueBioinformaticsGeoMx DSPMultiplex IF/IHCRNAseq

Jan 2025 · Med

Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside

Bone and soft tissueBreastCentral nervous systemEndocrineGastrointestinalGenitourinaryGynecologicHead and neckSkinThoracicBiomarker analysisBiomarker discoveryDiscoveryTLS scoringTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Dec 2024 · Cell Reports Medicine

Analysis of PD1, LAG3, TIGIT, and TIM3 expression in human lung adenocarcinoma reveals a 25-gene signature predicting immunotherapy response

GenitourinarySkinThoracicBiomarker analysisBiomarker discoveryDiscoveryTrialsFFPE tissueBioinformaticsMultiplex IF/IHCRNAseq

Oct 2024 · Journal of Hematology & Oncology

Predictive value of tumor microenvironment on pathologic response to neoadjuvant chemotherapy in patients with undifferentiated pleomorphic sarcomas

Bone and soft tissueBiomarker analysisTrialsFFPE tissuePlasmaMultiplex IF/IHCProteomics

Sep 2024 · Molecular Cancer

Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1 + antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics

GastrointestinalBiomarker analysisBiomarker discoveryDiscoverypre/post studyTrialsFFPE tissuePlasmaBioinformaticsGeoMx DSPMultiplex IF/IHCProteomics

Jul 2024 · BMC Cancer

AT-0174, a novel dual IDO1/TDO2 enzyme inhibitor, synergises with temozolomide to improve survival in an orthotopic mouse model of glioblasto

Central nervous systemPreclinical developmentMousePlasmaFlow cytometryMetabolomics

Jul 2024 · OncoImmunology

Faecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors

Bone and soft tissueGastrointestinalSkinThoracicDC assaysPreclinical developmentT cell assaysMousePBMCCytokine analysisFlow cytometry

Jul 2024 · Biomarker Research

Deciphering the correlation between metabolic activity through 18F-FDG-PET/CT and immune landscape in soft-tissue sarcomas: an insight from the NEOSARCOMICS study

Bone and soft tissueBiomarker analysisBiomarker discoveryDiscoveryTLS scoringTrialsFFPE tissueFresh-frozen tissueBioinformaticsMultiplex IF/IHCRNAseq

Feb 2024 · Molecular Cancer

Reshaping the tumor microenvironment of cold soft-tissue sarcomas with oncolytic viral therapy: a phase 2 trial of intratumoral JX-594 combined with avelumab and low-dose cyclophosphamide

Bone and soft tissueBiomarker analysispre/post studyTrialsFFPE tissuePlasmaMultiplex IF/IHCProteomics

Feb 2024 · Molecular Cancer

Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study

Bone and soft tissueBiomarker analysispre/post studyTrialsFFPE tissueMultiplex IF/IHC

Feb 2024 · Clinical Cancer Research

TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non–Small Cell Lung Cancer

ThoracicBiomarker analysisBiomarker discoveryDiscoveryTarget discoveryTrialsBioinformaticsMultiplex IF/IHCProteomicsRNAseq

Nov 2023 · Cancer Research Communications

Antitumor Effects of PRMT5 Inhibition in Sarcomas

Bone and soft tissueDiscoveryTarget discoveryTumor cell linesBioinformaticsRNAseq

Sep 2023 · Clinical Cancer Research

Upregulation of Indoleamine 2,3-Dioxygenase 1 in Tumor Cells and Tertiary Lymphoid Structures is a Hallmark of Inflamed Non–Small Cell Lung Cancer

ThoracicB cell assaysBiomarker analysisBiomarker discoveryDiscoveryPreclinical developmentTLS scoringTrialsFFPE tissuePBMCBioinformaticsFlow cytometryGeoMx DSPMultiplex IF/IHCRNAseq

Jan 2023 · Laboratory Investigation

Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers

Bone and soft tissueGastrointestinalBiomarker analysisTLS scoringTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Dec 2022 · Experimental Hematology & Oncology

Phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced breast cancer

BreastBiomarker analysispre/post studyTrialsPlasmaBioinformaticsProteomics

Oct 2022 · Journal of Hematology & Oncology

Pembrolizumab combined with low-dose cyclophosphamide and intra-tumoral injection of the toll-like receptor 4 agonist G100 in patients with advanced pretreated soft tissue sarcoma: results from the PEMBROSARC basket study

Bone and soft tissueBiomarker analysispre/post studyTLS scoringTrialsFFPE tissuePlasmaBioinformaticsMultiplex IF/IHCProteomics

Oct 2022 · Journal of Hematology & Oncology

Randomized phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced soft-tissue sarcoma

Bone and soft tissueBiomarker analysispre/post studyTrialsPlasmaBioinformaticsProteomics

Jul 2022 · Annals of Oncology

Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors

Bone and soft tissueGastrointestinalGenitourinaryHead and neckSkinThoracicBiomarker analysisBiomarker discoveryDiscoveryPreclinical developmentT cell assaysTrialsFFPE tissueMousePBMCPlasmaBioinformaticsCytokine analysisFlow cytometryMetabolomicsMultiplex IF/IHC

Jun 2022 · Immunity

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

DC assaysDiscoveryTarget discoveryPBMCPlasmaMetabolomicsMultiplex IF/IHC

May 2022 · Annals of Oncology

Impact of acetaminophen on the efficacy of immunotherapy in cancer patients

Bone and soft tissueGastrointestinalGenitourinarySkinThoracicBiomarker analysisBiomarker discoveryDiscoveryPreclinical developmentTrialsMousePBMCPlasmaBioinformaticsCytokine analysisFlow cytometryProteomics

May 2022 · Nature Medicine

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

Bone and soft tissueBiomarker analysisTLS scoringTrialsFFPE tissueBioinformaticsGeoMx DSPMultiplex IF/IHC

May 2022 · Journal for ImmunoTherapy of Cancer

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies

ThoracicBiomarker analysisBiomarker discoveryDiscoverypre/post studyTrialsFFPE tissueBioinformaticsGeoMx DSP

Jan 2022 · Frontiers in Immunology

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

Bone and soft tissueBreastCentral nervous systemGastrointestinalGenitourinaryGynecologicHead and neckHematologicSkinThoracicBiomarker analysisBiomarker discoveryDiscoveryTarget discoveryTrials

Jan 2022 · European Journal of Cancer

Regorafenib–avelumab combination in patients with biliary tract cancer (REGOMUNE): a single-arm, open-label, phase II trial

GastrointestinalBiomarker analysispre/post studyTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Dec 2021 · Marine Drugs

Fucoidan Independently Enhances Activity in Human Immune Cells and Has a Cytostatic Effect on Prostate Cancer Cells in the Presence of Nivolumab

GenitourinaryPreclinical developmentT cell assaysTumor killing assaysImmune/tumor cell co-cultureLive-cell imaging

Dec 2021 · iScience

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

BreastDiscoveryTarget discoveryImmune/tumor cell co-cultureBioinformatics

Nov 2021 · Clinical Cancer Research

Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study

Bone and soft tissueGynecologicBiomarker analysispre/post studyTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Nov 2021 · iScience

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

BreastBiomarker discoveryDiscoveryPreclinical developmentTarget discoveryImmune/tumor cell co-cultureMouseBioinformaticsFlow cytometryMultiplex IF/IHCRNAseq

Aug 2021 · Annals of Oncology

Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance

Bone and soft tissueBreastEndocrineGastrointestinalGenitourinaryGynecologicHead and neckSkinThoracicBiomarker analysisBiomarker discoveryDiscoverypre/post studyTarget discoveryTrialsFFPE tissuePlasmaBioinformaticsMultiplex IF/IHCProteomics

Aug 2021 · Nature Cancer

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

Bone and soft tissueBreastEndocrineGastrointestinalGenitourinaryGynecologicHead and neckThoracicBiomarker analysisBiomarker discoveryDiscoverypre/post studyTLS scoringTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Jan 2021 · Clinical Cancer Research

Regorafenib-Avelumab Combination in Patients with Microsatellite Stable Colorectal Cancer (REGOMUNE): A Single-arm, Open-label, Phase II Trial

GastrointestinalBiomarker analysispre/post studyTrialsFFPE tissueBioinformaticsMultiplex IF/IHC

Jul 2020 · Biomarker Research

Inactivating mutations in genes encoding for components of the BAF/PBAF complex and immune-checkpoint inhibitor outcome

GenitourinaryGynecologicSkinBiomarker discoveryDiscoveryBioinformatics

Mar 2020 · Frontiers in Immunology

IDO Targeting in Sarcoma: Biological and Clinical Implications

Bone and soft tissueBiomarker analysisBiomarker discoveryDiscoveryPreclinical developmentFFPE tissueFresh-frozen tissueImmune/tumor cell co-cultureMousePlasmaBioinformaticsFlow cytometryMetabolomicsMultiplex IF/IHCRNAseq

Feb 2020 · The Lancet Oncology

Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial

Bone and soft tissueBiomarker analysisTrialsPlasmaProteomics

Nov 2018 · Nature Communications

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

SkinBiomarker discoveryDiscoveryTarget discoveryImmune/tumor cell co-cultureMouseRNAseq

Jun 2017 · JAMA Oncology

Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas: A Phase 2 Clinical Trial

Bone and soft tissueBiomarker analysisTrialsFFPE tissuePlasmaMetabolomicsMultiplex IF/IHC

Apr 2015 · PLOS ONE

Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers

BreastGastrointestinalBiomarker analysisDiscoveryTarget validationFFPE tissueMultiplex IF/IHC

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