Onward Therapeutics: Characterizing the mechanism of action of a bispecific antibody in a pre-IND setting
High grade serous ovarian cancer ascites exhibit an impaired immune environment – immunosuppressive & protumoral – detrimental to the immune response
Background Malignant ovarian cancer ascites are increasingly recognized as major contributors to tumorigenesis and cancer progression. Ascites create a complex microenvironment where tumor cells interact with soluble mediators, metabolic factors, and immune cells. These interactions can influence tumor behavior, immune response, and treatment sensitivity. Characterizing the immune and metabolic composition of ovarian cancer ascites, together […]
Ovarian cancer ascites display altered immune environment featured by enhanced soluble factors and suppressive cellular context
Background The tumor microenvironment of epithelial ovarian cancer is unique among solid tumors, as tumor cells can shape their own microenvironment through the formation of malignant ascites. These ascites represent a complex mixture of soluble factors and cellular components. They are known to be enriched in macrophages, which have been suggested to acquire an M2-like […]
Multiparametric cytokine profiling across immune cell-based assay platforms
Cytokine release is a key functional readout for assessing immune cell activation, modulation, and effector function in immuno-oncology. While phenotypic analysis provides valuable information on immune cell identity and activation status, the measurement of cytokines released by immune cells offers a direct functional surrogate of their biological activity. Depending on the assay context, cytokine profiling […]