How ADORA2B drives metastasis in pleomorphic sarcoma — and why it’s a tractable target
How tertiary lymphoid structures predict pembrolizumab response in soft-tissue sarcoma — and why plasma cells matter
High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas
Background The composition of the tumor microenvironment is a key determinant of effective anti-tumor immunity. In sarcomas, the presence of organized B and T cell aggregates, known as tertiary lymphoid structures, has recently been shown to predict response to immune checkpoint blockers. However, only a minority of patients derive clinical benefit from immune checkpoint […]
How CD95 keeps NF-κB switched off in triple-negative breast cancer — and what its loss unleashes
How CD95/Fas helps triple-negative breast cancer escape NK-cell control in preclinical models
