How to screen for mature tertiary lymphoid structures in routine pathology — a standardized method validated across 357 tumors
Why the TLR4 agonist G100 boosted T cells but not PD-1 response in “cold” soft tissue sarcoma
How tertiary lymphoid structures predict pembrolizumab response in soft-tissue sarcoma — and why plasma cells matter
High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas
Background The composition of the tumor microenvironment is a key determinant of effective anti-tumor immunity. In sarcomas, the presence of organized B and T cell aggregates, known as tertiary lymphoid structures, has recently been shown to predict response to immune checkpoint blockers. However, only a minority of patients derive clinical benefit from immune checkpoint […]
How mature TLSs identify solid tumor patients more likely to benefit from PD-1 blockade
B Cells and Tertiary Lymphoid Structures as Key Players in Anti-Tumor Immune Response
B cells are increasingly recognized as key contributors to anti-tumor immune responses and response to cancer immunotherapy. Recent studies have demonstrated the association between B cell-enriched immune signatures and response to immunotherapy across several cancer indications, including melanoma, renal cell carcinoma, and sarcoma. In responding patients, B cells are frequently enriched within organized lymphoid aggregates […]